Regional, Layer, and Cell-Type-Specific Connectivity of the Mouse Default Mode Network

Summary The evolutionarily conserved default mode network (DMN) is a distributed set of brain regions coactivated during resting states that vulnerable to disorders. How disease affects the DMN unknown, but detailed anatomical descriptions could provide clues. Mice offer an opportunity investigate structural connectivity across spatial scales with cell-type resolution. We co-registered maps from functional magnetic resonance imaging and axonal tracing experiments into 3D Allen mouse reference atlas. find consists preferentially interconnected cortical regions. As population, layer 2/3 (L2/3) neurons project almost exclusively other regions, whereas L5 in out DMN. In retrosplenial cortex, core region, we identify two projection types differentiated by in- or out-DMN targets, laminar position, gene expression. These results multi-scale description correlates